Interactions dietary components with expression level of breast cancer-related genes

Abstract Background Dietary components can influence the effects of genetic background in breast cancer (BC). This review study aimed to investigate effect dietary on expression level BC-related genes. Methods In this narrative review, Embase, PubMed, PsycInfo, and Cochrane databases were used collect related papers with interactions BC, genetics, intake. Appropriate keywords such as gene expression, mutation, nutrient, diet (alone together) applied for data collection. Results The association BC some genes including BC1 ( BRCA1 ), human epidermal growth factor receptor 2 HER2 fat mass obesity-associated FTO ) be affected by components. Moderate B12 supplementation may protective against people inherited mutation BRCA . olive oil have a through several mechanisms suppressing HER-2 expression. Furthermore, high glycemic index foods increase risk activation phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) pathway up-regulation Conclusion There are between genes, macronutrients, micronutrients, phytochemicals regulate Further longitudinal studies needed confirm associations discover underlying mechanisms.